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Article

X-Chromosome Inactivation and Escape from X Inactivation in Mouse.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Ma Wenxiu, Bonora Giancarlo, Berletch Joel B, Deng Xinxian, Noble William S, Disteche Christine M

Abstract excerpt

X chromosome inactivation silences one X chromosome in female mammals. However, this silencing is incomplete, and some genes escape X inactivation. We describe methods to determine the chromosome-wide X inactivation status of genes in tissues or cell lines derived from mice using a combination of skewing of X inactivation and allele-specific analyses of gene expression based on RNA-seq.

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Share to Embryo, Mammalian
Share to Epigenomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Gene Expression Regulation, Developmental

Share to Mice, Inbred C57BL

Share to Sequence Analysis, RNA

Share to X Chromosome Inactivation

Source

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Identifiers

PMID: 30218369
DOI: 10.1007/978-1-4939-8766-5_15
PMCID: PMC6269188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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