Article

Loss of chromosome Y shapes the immune cell fate with aging in men

2025-06-02

Abstract excerpt

The loss of chromosome Y (LOY) in leukocytes is the most prevalent form of clonal mosaicism observed in older men. It is associated with all major causes of mortality, including cardiovascular diseases and cancer. However, LOY effect on individual immune-cell lineages remains unclear. Here, we used single-cell RNA sequencing data from Onek1K cohort and showed that LOY has a wide effect on cell fate across immune c...

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Literature Corpus work: 8ca4227a-77ac-5565-8b16-24038a5be84c
DOI: 10.1101/2025.06.01.25328624

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