Article

Landscape of X chromosome inactivation across human tissues

2016-09-19

Abstract excerpt

X chromosome inactivation (XCI) silences the transcription from one of the two X chromosomes in mammalian female cells to balance expression dosage between XX females and XY males. XCI is, however, characteristically incomplete in humans: up to one third of X-chromosomal genes are expressed from both the active and inactive X chromosomes (Xa and Xi, respectively) in female cells, with the degree of “escape” from i...

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Literature Corpus work: 4c60966b-a69a-52f0-aa07-b574782f8e7b
DOI: 10.1101/073957

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