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Article

X-chromosome inactivation in human iPSCs provides insight into X-regulated gene expression in autosomes.

Genome biology - 31 May 2024

Topa Hande, Benoit-Pilven Clara, Tukiainen Taru, Pietiläinen Olli

Abstract excerpt

BACKGROUND: Variation in X chromosome inactivation (XCI) in human-induced pluripotent stem cells (hiPSCs) can impact their ability to model biological sex biases. The gene-wise landscape of X chromosome gene dosage remains unresolved in female hiPSCs. To characterize patterns of de-repression and escape from inactivation, we performed a systematic survey of allele specific expression in 165 female hiPSC lines....

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Share to Alleles
Share to Chromosomes, Human, X
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Induced Pluripotent Stem Cells

Share to RNA, Long Noncoding

Share to X Chromosome Inactivation

Source

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Identifiers

PMID: 38822397
DOI: 10.1186/s13059-024-03286-8
PMCID: PMC11143737

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