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<i>DNMT3A</i> knockouts in human iPSCs prevent <i>de novo</i> DNA methylation and reveal growth advantage during hematopoietic differentiation

2021-12-15

Abstract excerpt

<h4>Summary</h4> DNA methyltransferase 3A ( DNMT3A ) is a frequently mutated gene in many hematological malignancies, indicating that it may be essential for hematopoietic differentiation. Here, we addressed the functional relevance of DNMT3A for differentiation of human induced pluripotent stem cells (iPSCs) by knocking out exon 2, 19, or 23. Exon 19 -/- and 23 -/- lines revealed absence of almost the entire...

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Literature Corpus work
f7d3b18f-1e5f-5fbb-a347-5f46d74623fc
DOI
10.1101/2021.12.15.472782
Open publication

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<i>DNMT3A</i> knockouts in human iPSCs prevent <i>de novo</i> DNA methylation and reveal growth advantage during hematopoietic differentiationDOI 10.1101/2021.12.15.472782
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