Article

Joint profiling of 5mC, 5hmC, and the transcriptome in single cells identifies factors responsible for genome-wide DNA methylation erasure in human primordial germ cell maturation

2025-04-06

Abstract excerpt

<h4>ABSTRACT</h4> Reprogramming of DNA methylation plays a vital role in the establishment of cell identity during early mammalian development. To gain deeper mechanistic insights into this process requires capturing the entire dynamics of DNA methylation – both 5-methylcytosine (5mC) and its downstream oxidation product 5-hydroxymethylcytosine (5hmC) – in individual cells. Therefore, in this work, we report a ne...

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Literature Corpus work: a49317dd-5bb0-5e6f-8c46-dd88993a4a16
DOI: 10.1101/2025.04.01.646736

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