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Article

Dnmt3a is essential for hematopoietic stem cell differentiation.

Nature genetics - 4 Dec 2011

Challen Grant A, Sun Deqiang, Jeong Mira, Luo Min, Jelinek Jaroslav, Berg Jonathan S, Bock Christoph, Vasanthakumar Aparna, Gu Hongcang, Xi Yuanxin, Liang Shoudan, Lu Yue, Darlington Gretchen J, Meissner Alexander, Issa Jean-Pierre J, Godley Lucy A, Li Wei, Goodell Margaret A

Abstract excerpt

Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely unknown. Using conditional ablation, we show that Dnmt3a loss progressively impairs hematopoietic stem cell (HSC) dif...

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Identifiers

PMID: 22138693
DOI: 10.1038/ng.1009
PMCID: PMC3637952

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22138693-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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