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Article

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo

1 Apr 2018

Abstract excerpt

Somatic mutations in DNMT3A are recurrent events across a range of blood cancers. Dnmt3a loss of function in hematopoietic stem cells (HSCs) skews divisions toward self-renewal at the expense of differentiation. Moreover, DNMT3A mutations can be detected in the blood of aging individuals, indicating that mutant cells outcompete normal HSCs over time. It is important to understand how these mutations provide a...

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PMID: 29617651
DOI: 10.1016/j.celrep.2018.03.025

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