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Article

Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation.

Blood - 22 Jan 2015

Celik Hamza, Mallaney Cates, Kothari Alok, Ostrander Elizabeth L, Eultgen Elizabeth, Martens Andrew, Miller Christopher A, Hundal Jasreet, Klco Jeffery M, Challen Grant A

Abstract excerpt

Genome sequencing studies of patient samples have implicated the involvement of various components of the epigenetic machinery in myeloid diseases, including the de novo DNA methyltransferase DNMT3A. We have recently shown that Dnmt3a is essential for hematopoietic stem cell differentiation. Here, we investigated the effect of loss of Dnmt3a on hematopoietic transformation by forcing the normally quiescent...

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Identifiers

PMID: 25416276
DOI: 10.1182/blood-2014-08-594564
PMCID: PMC4304107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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