Article

Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem Cells

2024-05-10

Abstract excerpt

<h4>SUMMARY</h4> Epigenetic mechanisms are crucial for developmental programming and can be disrupted by environmental stressors, increasing susceptibility to disease. This has sparked interest in therapies for restoring epigenetic balance, but it remains uncertain whether disordered epigenetic mechanisms can be fully corrected. Disruption of DNA methyltransferase 1 (DNMT1), responsible for DNA methylation mainte...

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Literature Corpus work: e832ba58-c3df-59ca-be74-f7e4ad6e99f9
DOI: 10.1101/2024.05.07.592204

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