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Single-cell multi-omics of human clonal hematopoiesis reveals that <i>DNMT3A</i> R882 mutations perturb early progenitor states through selective hypomethylation

2022-01-16

Abstract excerpt

<h4>ABSTRACT</h4> Somatic mutations in cancer genes have been ubiquitously detected in clonal expansions across healthy human tissue, including in clonal hematopoiesis. However, mutated and wildtype cells are morphologically and phenotypically similar, limiting the ability to link genotypes with cellular phenotypes. To overcome this limitation, we leveraged multi-modality single-cell sequencing, capturing the mut...

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Literature Corpus work: 05b9284e-ab2c-5c90-b362-00db3c545b8c
DOI: 10.1101/2022.01.14.476225

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Single-cell multi-omics of human clonal hematopoiesis reveals that <i>DNMT3A</i> R882 mutations perturb early progenitor states through selective hypomethylationDOI 10.1101/2022.01.14.476225Read

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