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The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells

2021-09-12

Abstract excerpt

<h4>Background</h4> DNA methylation plays an important role in regulating gene expression in mammals. The covalent DNMT1 inhibitors 5-azacytidine and decitabine are widely used in research to reduce DNA methylation levels, but they impart severe cytotoxicity which limits their demethylation capability and confounds interpretation of experiments. Recently, a non-covalent inhibitor of DNMT1 called GSK-3484862 was d...

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Literature Corpus work
fd3cbc7b-77ba-54a1-a7f9-8353ad76c09d
DOI
10.1101/2021.09.12.459949
Open publication

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The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cellsDOI 10.1101/2021.09.12.459949
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