Article

Analysis of genomic DNA methylation and gene transcription modulation induced by <i>DNMT3A</i> deficiency in HEK293 cells

2020-07-12

Abstract excerpt

DNA methylation is an important epigenetic modification associated with transcriptional repression, and plays key roles in normal cell growth as well as oncogenesis. Among the three main DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B), DNMT3A mediates de novo DNA methylation with partial functional redundancy with DNMT3B. However, the general effects of DNMT3A and its downstream gene regulation profile are yet...

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Literature Corpus work: 0de6d35f-95d7-53c3-84d1-2825706dca85
DOI: 10.1101/2020.07.11.198895

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