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DNMT1 can induce primary germ layer differentiation through de novo DNA methylation

29 May 2024

Abstract excerpt

DNA methyltransferases and Ten-Eleven Translocation (TET) proteins regulate the DNA methylation and demethylation cycles during mouse embryonic development. Although DNMT1 mainly plays a role in the maintenance of DNA methylation after DNA replication, it is also reported to possess de novo methyltransferase capacity. However, its physiological significance remains unclear. Here, we demonstrate that full-length...

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PMID: 38811355
DOI: 10.1111/gtc.13130

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