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Hematopoietic differentiation persists in human iPSCs defective in de novo DNA methylation

15 Jun 2022

Abstract excerpt

Abstract Background DNA methylation is involved in the epigenetic regulation of gene expression during developmental processes and is primarily established by the DNA methyltransferase 3A (DNMT3A) and 3B (DNMT3B). DNMT3A is one of the most frequently mutated genes in clonal hematopoiesis and leukemia, indicating that it plays a crucial role for hematopoietic differentiation. However, the functional relevance of...

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PMID: 35705990
DOI: 10.1186/s12915-022-01343-x

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