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Article

Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo.

Nature cell biology - 1 Nov 2019

Brumbaugh Justin, Kim Ik Soo, Ji Fei, Huebner Aaron J, Di Stefano Bruno, Schwarz Benjamin A, Charlton Jocelyn, Coffey Amy, Choi Jiho, Walsh Ryan M, Schindler Jeffrey W, Anselmo Anthony, Meissner Alexander, Sadreyev Ruslan I, Bernstein Bradley E, Hock Hanno, Hochedlinger Konrad

Abstract excerpt

Development and differentiation are associated with profound changes to histone modifications, yet their in vivo function remains incompletely understood. Here, we generated mouse models expressing inducible histone H3 lysine-to-methionine (K-to-M) mutants, which globally inhibit methylation at specific sites. Mice expressing H3K36M developed severe anaemia with arrested erythropoiesis, a marked haematopoietic...

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Identifiers

PMID: 31659274
DOI: 10.1038/s41556-019-0403-5
PMCID: PMC6858577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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