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Article

Analysis of Genomic DNA Methylation and Gene Transcription Modulation Induced by DNMT3A Deficiency in HEK293 Cells

2020-08-17

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> DNA methylation is an important epigenetic modification associated with transcriptional repression, and plays key roles in normal cell growth as well as oncogenesis. Among the three main DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B), DNMT3A mediates <italic>de novo</italic> DNA methylation with partial functional redundancy with DNMT3B. However, the general...

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Literature Corpus work
8632b8a7-fc24-57f9-969b-72a7ff06838b
DOI
10.21203/rs.3.rs-53272/v1
Open publication

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Analysis of Genomic DNA Methylation and Gene Transcription Modulation Induced by DNMT3A Deficiency in HEK293 CellsDOI 10.21203/rs.3.rs-53272/v1
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