Article

Site-Specific Inhibition of Translation Initiation via 2’-O-methylation

2025-06-17

Abstract excerpt

<h4>ABSTRACT</h4> Translation initiation involves a concerted set of intermolecular interactions that efficiently recognize optimal AUG start codons. However, translation initiation complexes often start at upstream non-optimal AUGs or near-cognate codons, leading to the expression of upstream Open Reading Frames (uORFs). Using retrospective analyses of translation preinitiation cryo-EM structures, we identified...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f74bd38c-b318-5e5a-9b50-17836c535406
DOI: 10.1101/2025.06.14.659565

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Site-Specific Inhibition of Translation Initiation via 2’-O-methylationDOI 10.1101/2025.06.14.659565Read

Decoding the Sequence Requirements for Translation InitiationSemantic proximity Read

Mechanisms Leading to the Loss of AUG Codon Function as a Translation InitiatorSemantic proximity Read

Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation.Semantic proximity Read

Regulatory start-stop elements in 5’ untranslated regions pervasively modulate translationSemantic proximity Read

Functional characterization of 5’ UTR <i>cis</i> -acting sequence elements that modulate translational efficiency in <i>P. falciparum</i> and humansSemantic proximity Read

The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4ASemantic proximity Read

Decoding m <sup>6</sup> Am by simultaneous transcription-start mapping and methylation quantificationSemantic proximity Read

PCIF1 catalyzes m6Am mRNA methylation to regulate gene expressionSemantic proximity Read

Structural and Functional Insights into Human Re-initiation Complexes.Semantic proximity Read

Translation initiation by the Kozak mRNA sequence is based on a conformational readout on the ribosomeSemantic proximity Read

Base-resolution mapping reveals distinct m <sup>1</sup> A methylome in nuclear- and mitochondrial-encoded transcriptsSemantic proximity Read

Unbiased screen of human transcriptome reveals an unexpected role of 3′UTRs in translation initiationSemantic proximity Read