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Article

Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation.

Nature communications - 24 Aug 2016

Martin Franck, Ménétret Jean-François, Simonetti Angelita, Myasnikov Alexander G, Vicens Quentin, Prongidi-Fix Lydia, Natchiar S Kundhavai, Klaholz Bruno P, Eriani Gilbert

Abstract excerpt

Eukaryotic mRNAs often contain a Kozak sequence that helps tether the ribosome to the AUG start codon. The mRNA of histone H4 (h4) does not undergo classical ribosome scanning but has evolved a specific tethering mechanism. The cryo-EM structure of the rabbit ribosome complex with mouse h4 shows that the mRNA forms a folded, repressive structure at the mRNA entry site on the 40S subunit next to the tip of helix...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27554013
DOI: 10.1038/ncomms12622
PMCID: PMC4999511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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