Article

Unbiased screen of human transcriptome reveals an unexpected role of 3′UTRs in translation initiation

2021-05-28

Abstract excerpt

Although most eukaryotic mRNAs require a 5′-cap for translation initiation, some can also be translated through a poorly studied cap-independent pathway. Here we developed a circRNA-based system and unbiasedly identified more than 10,000 sequences in the human transcriptome that contain Cap-independent Translation Initiators (CiTIs). Surprisingly, most of the identified CiTIs are located in 3′UTRs, which mainly pr...

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Literature Corpus work: b147c947-2ab5-50dc-821b-7ebbcab1714a
DOI: 10.1101/2021.05.28.446092

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