Article

Decoding m <sup>6</sup> Am by simultaneous transcription-start mapping and methylation quantification

2024-10-17

Abstract excerpt

<h4>ABSTRACT</h4> N 6 ,2’- O -dimethyladenosine (m 6 Am) is a modified nucleotide located at the first transcribed position in mRNA and snRNA that is essential for diverse physiological processes. m 6 Am mapping methods assume each gene uses a single start nucleotide. However, gene transcription usually involves multiple start sites, generating numerous 5’ isoforms. Thus, gene levels annotations cannot capture...

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Literature Corpus work: 618a9d51-aa56-5448-bb47-8252e7584a2c
DOI: 10.1101/2024.10.16.618717

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