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Article

Structural and Functional Insights into Human Re-initiation Complexes.

Molecular cell - 3 Aug 2017

Weisser Melanie, Schäfer Tanja, Leibundgut Marc, Böhringer Daniel, Aylett Christopher Herbert Stanley, Ban Nenad

Abstract excerpt

After having translated short upstream open reading frames, ribosomes can re-initiate translation on the same mRNA. This process, referred to as re-initiation, controls the translation of a large fraction of mammalian cellular mRNAs, many of which are important in cancer. Key ribosomal binding proteins involved in re-initiation are the eukaryotic translation initiation factor 2D (eIF2D) or the homologous complex...

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Identifiers

PMID: 28732596
DOI: 10.1016/j.molcel.2017.06.032

Genes

DENR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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