Article

PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression

2018-12-02

Abstract excerpt

<h4>Summary</h4> mRNA modifications play an important role in regulating gene expression. One of the most abundant mRNA modifications is N6,2-O-dimethyladenosine (m6Am). Here, we demonstrate that m6Am is an evolutionarily conserved mRNA modification mediated by the Phosphorylated CTD Interacting Factor 1 (PCIF1), which catalyzes m6A methylation on 2-O-methylated adenine located at the 5’ ends of mRNAs. Furthermor...

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Literature Corpus work: 294cae8a-161b-54d7-9ec7-b8af08f036b7
DOI: 10.1101/484931

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