Article

Decoding the Sequence Requirements for Translation Initiation

2026-05-12

Abstract excerpt

Accurate selection of start codons by ribosomes is a fundamental determinant of proteome composition. Although the ‘Kozak sequence’—an 8-nucleotide sequence flanking the start codon—has long been viewed as the primary determinant of initiation in eukaryotes, it fails to explain the large diversity of start codon usage across transcripts. Here we combine massively parallel reporter assays, bioinformatics, machine l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 95318f87-d54a-55e1-b170-b7ede282991f
DOI: 10.64898/2026.05.12.723742

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Decoding the Sequence Requirements for Translation InitiationDOI 10.64898/2026.05.12.723742Read

Mechanisms Leading to the Loss of AUG Codon Function as a Translation InitiatorSemantic proximity Read

A codon-sensitive conformational switch gates commitment to translation start sitesSemantic proximity Read

Quantitative analysis of mammalian translation initiation sites by FACS-seq.Semantic proximity Read

Predicting the translation efficiency of messenger RNA in mammalian cellsSemantic proximity Read

NeuroTIS+: An Improved Method for Translation Initiation Site Prediction in Full-Length mRNA Sequence via Structural InformationSemantic proximity Read

Analysis of RNA translation with a deep learning architecture provides new insight into translation controlSemantic proximity Read

ExtRamp Online: Enabling ramp sequence calculations via an intuitive web interface.Semantic proximity Read

Site-Specific Inhibition of Translation Initiation via 2’-O-methylationSemantic proximity Read

Mutate and observe: utilizing deep neural networks to investigate the impact of mutations on translation initiation.Semantic proximity Read

Mammalian Alternative Translation Initiation Is Mostly Nonadaptive.Semantic proximity Read

Translation initiation by the Kozak mRNA sequence is based on a conformational readout on the ribosomeSemantic proximity Read

Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor ComplexesSemantic proximity Read