Article

The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A

2022-12-07

Abstract excerpt

<h4>Summary</h4> Initiation of mRNA translation is a key regulatory step in gene expression in all eukaryotes. Canonical initiation of translation in eukaryotes involves recruitment of the 43S preinitiation complex to the 5′ end of mRNA by the cap-binding complex eIF4F to form the 48S initiation complex (48S), followed by scanning along the mRNA until the start codon is selected.1–8 We have previously shown that...

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Literature Corpus work: 459d20d9-7ec2-5283-8443-57c3963037d7
DOI: 10.1101/2022.12.07.519490

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