Article

Regulatory start-stop elements in 5’ untranslated regions pervasively modulate translation

2021-07-26

Abstract excerpt

Sequence elements within the 5’ untranslated region (UTR) of eukaryotic genes, e.g. upstream open reading frames (uORFs), control translation of eukaryotic genes. We describe an element consisting of a start codon immediately followed by a stop codon which is distinct from uORFs in the lack of an elongation step. Start-stops have been described for specific cases, but their widespread impact has been overlooked. S...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7ebd40e5-1235-5f14-a4df-a88371dfc18a
DOI: 10.1101/2021.07.26.453809

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regulatory start-stop elements in 5’ untranslated regions pervasively modulate translationDOI 10.1101/2021.07.26.453809Read

Mechanisms Leading to the Loss of AUG Codon Function as a Translation InitiatorSemantic proximity Read

Unbiased screen of human transcriptome reveals an unexpected role of 3′UTRs in translation initiationSemantic proximity Read

uORFdb--a comprehensive literature database on eukaryotic uORF biology.Semantic proximity Read

3S-DB Identifies an RNA Repository Facilitating Stop Codon Readthrough for Selenocysteine Insertion and Selenoproteome ExpansionSemantic proximity Read

Role of 5'- and 3'-untranslated regions of mRNAs in human diseases.Semantic proximity Read

Some like it translated: small ORFs in the 5′UTRSemantic proximity Read

Eukaryotic start and stop translation sites.Semantic proximity Read

Hidden stop codons orchestrate mRNA fate by ambushing ribosomal frameshifting associated with codon usageSemantic proximity Read

Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiationSemantic proximity Read

Disrupting upstream translation in mRNAs leads to loss-of-function associated with human diseaseSemantic proximity Read

Emerging links between initiation of translation and human diseases.Semantic proximity Read

Translation of numerous upstream open reading frames rather than their products is essential for proliferation of human cells of distinct originSemantic proximity Read