Article

Neuroimmune cortical organoids overexpressing C4A exhibit multiple schizophrenia endophenotypes

2023-01-20

Abstract excerpt

Elevated expression of the complement component 4A (C4A) protein has been linked to an increased risk of schizophrenia (SCZ). However, there are few human models available to study the mechanisms by which C4A contributes to the development of SCZ. In this study, we established a C4A overexpressing neuroimmune cortical organoid (NICO) model, which includes mature neuronal cells, astrocytes, and functional microglia...

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Literature Corpus work: f6993de5-6687-5476-b085-f4c33696514c
DOI: 10.1101/2023.01.20.524955

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