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Article

Complement component C4 levels in the cerebrospinal fluid and plasma of patients with schizophrenia.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2021

Gallego Juan A, Blanco Emily A, Morell Christopher, Lencz Todd, Malhotra Anil K

Abstract excerpt

Abnormalities in the complement system have been described in patients with schizophrenia, with those individuals having greater frequency of complement component 4A (C4A) alleles and higher C4A transcript levels in postmortem brain tissue. Importantly, abnormalities in C4A and other complement molecules have been associated with synaptic pruning abnormalities that occur during neurodevelopment. A few studies...

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PMID: 32961544
DOI: 10.1038/s41386-020-00867-6
PMCID: PMC8115103

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