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Article

Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia.

Nature neuroscience - 1 Jun 2021

Kim Minsoo, Haney Jillian R, Zhang Pan, Hernandez Leanna M, Wang Lee-Kai, Perez-Cano Laura, Loohuis Loes M Olde, de la Torre-Ubieta Luis, Gandal Michael J

Abstract excerpt

The most significant common variant association for schizophrenia (SCZ) reflects increased expression of the complement component 4A (C4A). Yet, it remains unclear how C4A interacts with other SCZ risk genes or whether the complement system more broadly is implicated in SCZ pathogenesis. Here, we integrate several existing, large-scale genetic and transcriptomic datasets to interrogate the functional role of the...

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Identifiers

PMID: 33958802
DOI: 10.1038/s41593-021-00847-z
PMCID: PMC8178202

Genes

C4A

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