Article
hiPSC-Derived Astrocytes From Individuals With Schizophrenia Induce a Dystrophic Phenotype in Microglial-Like Cells.
Glia - 1 Jan 2026
Cardozo Pablo L, Lee Chia-Yi, Lacerda Juliana P S, Fahel Júlia S, Trindade Pablo, Vitória Gabriela, Chicaybam Leonardo, Cordeiro Rafaela C, de Faria Isaque J S, Silva Nathália C, Todjro Yaovi M H, Maciel Joana C do P, Bonamino Martin H, Vieira Luciene B, Cruz Breno F, Nicolato Rodrigo, Brennand Kristen J, Rehen Stevens K, Ribeiro Fabíola M
Abstract excerpt
Neuroinflammation, particularly astrocyte reactivity, is increasingly linked to schizophrenia (SCZ). Yet, the crosstalk between astrocytes and microglia in SCZ, especially under pro-inflammatory conditions, remains unclear. Here, we employed human induced-pluripotent stem cells to compare how astrocytes from five age-matched individuals with SCZ and five neurotypical controls, upon stimulation with TNF-α,...
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