Article

Increased microglial synapse elimination in patient-specific models of schizophrenia

2017-12-08

Abstract excerpt

Schizophrenia patients display decreased synaptic density in postmortem studies, suggesting aberrant microglial synapse elimination during neurodevelopment. Here, we use cellular reprogramming to create patient-specific in vitro models of microglia-mediated synapse engulfment that demonstrate increased synapse elimination in schizophrenia-derived models compared to healthy controls. We show that excessive synapti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b4da62e3-262a-5729-b32b-3569c1e87f30
DOI: 10.1101/231290

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Increased microglial synapse elimination in patient-specific models of schizophreniaDOI 10.1101/231290Read

Kynurenic acid promotes activity-dependent synaptic pruning in schizophreniaSemantic proximity Read

Regulation of synaptic connectivity in schizophrenia by mutual neuron-microglia interactionSemantic proximity Read

Neuroimmune cortical organoids overexpressing C4A exhibit multiple schizophrenia endophenotypesSemantic proximity Read

Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoidsSemantic proximity Read

Atypical antipsychotics alter microglial functions via astrocyte-derived extracellular vesiclesSemantic proximity Read

Identifying brain-penetrant small molecule modulators of human microglia using a cellular model of synaptic pruningSemantic proximity Read

Functional Genomic Profiling of Schizophrenia-Associated Genes Reveals Key Microglial RegulatorsSemantic proximity Read

Loss of function in the autism and schizophrenia-associated gene <i>CYFIP1</i> in human microglia supports a role in synaptic pruningSemantic proximity Read

Human microglia in brain assembloids display region- specific diversity and respond to hyperexcitable neurons carrying <i>SCN2A</i> mutation: Microglial diversity and response in assembloidsSemantic proximity Read

Cerebrospinal fluid concentration of complement component 4A is increased in first-episode schizophreniaSemantic proximity Read

Morphological and transcriptomic analyses of stem cell-derived cortical neurons reveal mechanisms underlying synaptic dysfunction in schizophreniaSemantic proximity Read

hiPSC-derived astrocytes from individuals with schizophrenia induce a dystrophic phenotype in microglial-like cellsSemantic proximity Read