Article

Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia

2020-03-04

Abstract excerpt

The most significant common variant association for schizophrenia (SCZ) reflects increased expression of the complement component 4A ( C4A ). Yet, it remains unclear how C4A interacts with other SCZ risk genes and whether the complement system is more broadly implicated in SCZ pathogenesis. Here, we integrate several existing, large-scale genetic and transcriptomic datasets to interrogate the functional role of...

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Literature Corpus work: e00b2c0f-9f72-5b41-b49b-327be25b4f73
DOI: 10.1101/2020.03.03.975722

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