Article

hiPSC-derived astrocytes from individuals with schizophrenia induce a dystrophic phenotype in microglial-like cells

2024-09-21

Abstract excerpt

<h4>ABSTRACT</h4> Neuroinflammation, particularly astrocyte reactivity, is increasingly linked to schizophrenia (SCZ). Yet, the crosstalk between astrocytes and microglia in SCZ, especially under pro-inflammatory conditions, remains unclear. Here, we employed human induced-pluripotent stem cells to compare how astrocytes from five age-matched individuals with SCZ and five neurotypical controls, upon stimulation w...

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Literature Corpus work: 28a56784-c0f2-51a0-93dd-2e188bfe7af0
DOI: 10.1101/2024.09.20.614161

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