Article

CUB and Sushi Multiple Domains 1 (CSMD1) opposes the complement cascade in neural tissues

2020-09-12

Abstract excerpt

Schizophrenia risk is associated with increased gene copy number and brain expression of complement component 4 ( C4 ). Because the complement system facilitates synaptic pruning, the C4 association has renewed interest in a hypothesis that excessive pruning contributes to schizophrenia pathogenesis. However, little is known about complement regulation in neural tissues or whether such regulation could be relev...

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Literature Corpus work: 906a41b1-efc3-57b0-b2c6-e6c49e3c149d
DOI: 10.1101/2020.09.11.291427

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