Article

Heterogeneous complement and microglia activation mediates stress-induced synapse loss

2023-06-30

Abstract excerpt

Spatially heterogeneous synapse loss is a characteristic of many psychiatric and neurological disorders, but the underlying mechanisms are unclear. Here, we show that spatially-restricted complement activation mediates stress-induced heterogeneous microglia activation and synapse loss localized to the upper layers of the mouse medial prefrontal cortex (mPFC). Single cell RNA sequencing also reveals a stress-associ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e9cd6255-3cca-5246-9d5f-beaf9ff62604
DOI: 10.1101/2023.06.28.546889

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Heterogeneous complement and microglia activation mediates stress-induced synapse lossDOI 10.1101/2023.06.28.546889Read

Neuroimmune cortical organoids overexpressing C4A exhibit multiple schizophrenia endophenotypesSemantic proximity Read

Complement and microglia mediate early synapse loss in Alzheimer mouse modelsSemantic proximity Read

C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brainSemantic proximity Read

Sparse Neuronal C4 Elevation Induces Network-Wide Transcriptomic and Lipid-Droplet Remodeling in the Cortical MicroenvironmentSemantic proximity Read

Complement-dependent synapse loss and microgliosis in a mouse model of multiple sclerosisSemantic proximity Read

Regional and sub-regional microglial heterogeneity in the steady-state mouse brain and retinaSemantic proximity Read

Dark microglia: A new phenotype predominantly associated with pathological states.Semantic proximity Read

Whole-transcriptomic profiling of human cerebral cortex tissues reveals microglia-associated molecular subtypesSemantic proximity Read

CUB and Sushi Multiple Domains 1 (CSMD1) opposes the complement cascade in neural tissuesSemantic proximity Read

Amplified Microglial Dysfunction and Brain Lesions in Mouse Models for Comorbidity of Chronic Stress and Intracerebral HypoperfusionSemantic proximity Read

Ketogenic diet alters microglial morphology and changes the hippocampal lipidomic profile distinctively in stress susceptible <i>versus</i> resistant male mice upon repeated social defeatSemantic proximity Read

Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoidsSemantic proximity Read