Article
Elevated expression of complement C4 in the mouse prefrontal cortex causes schizophrenia-associated phenotypes.
Molecular psychiatry - 1 Jul 2021
Druart Mélanie, Nosten-Bertrand Marika, Poll Stefanie, Crux Sophie, Nebeling Felix, Delhaye Célia, Dubois Yaëlle, Mittag Manuel, Leboyer Marion, Tamouza Ryad, Fuhrmann Martin, Le Magueresse Corentin
Abstract excerpt
Accumulating evidence supports immune involvement in the pathogenesis of schizophrenia, a severe psychiatric disorder. In particular, high expression variants of C4, a gene of the innate immune complement system, were shown to confer susceptibility to schizophrenia. However, how elevated C4 expression may impact brain circuits remains largely unknown. We used in utero electroporation to overexpress C4 in the...
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