Article
Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth.
Genome biology - 7 Mar 2023
Hernandez Leanna M, Kim Minsoo, Zhang Pan, Bethlehem Richard A I, Hoftman Gil, Loughnan Robert, Smith Diana, Bookheimer Susan Y, Fan Chun Chieh, Bearden Carrie E, Thompson Wesley K, Gandal Michael J
Abstract excerpt
BACKGROUND: Increased expression of the complement component 4A (C4A) gene is associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in synaptic pruning; yet, it remains unclear the extent to which upregulation of C4A alters brain development or is associated with the risk for psychotic symptoms in childhood. Here, we perform a multi-ancestry phenome-wide association study in 7789...
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