Article

Sparse Neuronal C4 Elevation Induces Network-Wide Transcriptomic and Lipid-Droplet Remodeling in the Cortical Microenvironment

2025-05-29

Abstract excerpt

The complement component C4 regulates synaptic refinement and plasticity in the brain and has been implicated in multiple neurological and psychiatric disorders, with especially strong genetic evidence linking elevated C4A expression to schizophrenia. Although altered C4 expression has been associated with disease risk, it remains unclear whether localized C4 elevation in a small neuronal population is suffici...

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Literature Corpus work: d006543a-c5fb-581a-96fd-1250b0053387
DOI: 10.1101/2025.05.29.656749

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