Article

Cerebrospinal fluid concentration of complement component 4A is increased in first-episode schizophrenia

2021-08-24

Abstract excerpt

Excessive synapse loss is a core feature of schizophrenia and is linked to the complement component 4A gene ( C4A ). In two independent cohorts, we show that cerebrospinal fluid (CSF) C4A concentration is elevated in first-episode psychosis patients who develop schizophrenia and correlates with CSF measurements of synapse density. Using patient-derived cellular modeling, we find that disease-associated cytokines i...

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Literature Corpus work: 7f44f59f-b0df-5a52-aa05-4f31ea6900a7
DOI: 10.1101/2021.08.17.21262131

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