Article

Bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation

2023-07-07

Abstract excerpt

The aberrant localization of proteins in cells is a key factor in the development of various diseases, including cancer and neurodegenerative disease. To better understand and potentially manipulate protein localization for therapeutic purposes, we engineered bifunctional compounds that bind to proteins in separate cellular compartments. We show these compounds induce nuclear import of cytosolic cargoes, using nuc...

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Literature Corpus work: f60bb755-9856-53be-9582-df6b85d90bf5
DOI: 10.1101/2023.07.07.548101

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