DNA Partitioning Modulates Liquid-to-Solid Transitions and the Internal Microstructure of FUS Condensates

Abstract excerpt

Protein liquid-liquid phase separation has recently been recognized as an essential process involved in cellular functions, including transcription, translation, and DNA damage repair. However, a further liquid-to-solid transition (LST) of condensates due to mutation or external stimuli can result in aggregation, sometimes pathological. The unique ability of protein condensates to concentrate and sequester biomole...

Topics

Open a Topic to create a Post that cites this publication.

• Cell Nucleus
• Cytoplasm
• DNA
• Mutation
• Neoplasms
• Phenotype
• Protein Binding
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

b353b444-f0da-598c-8182-7c6acdb050b2

DOI

10.1101/2025.06.03.657213