Article

Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription

2021-08-17

Abstract excerpt

Gene activation by mammalian transcription factors (TFs) requires dynamic, multivalent, and selective interactions of their intrinsically disordered low-complexity domains (LCDs), but how such interactions mediate transcription remains unclear. It has been proposed that extensive LCD-LCD interactions culminating in liquid-liquid phase separation (LLPS) of TFs is the dominant mechanism underlying transactivation. H...

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Literature Corpus work: abf30324-7fe1-5941-ac53-f429c5c59e95
DOI: 10.1101/2021.08.16.456551

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