Article
Disparate leukemia mutations converge on nuclear phase-separated condensates.
Cell - 11 Dec 2025
Datar Gandhar K, Khabusheva Elmira, Anand Archish, Beale Joshua, Sadek Marwa, Chen Chun-Wei, Potolitsyna Evdokiia, Alcantara-Contessoto Nayara, Liu Guangyuan, De La Fuente Josephine, Dollinger Christina, Guzman Anna, Martell Alejandra, Wohlan Katharina, Maiti Abhishek, Short Nicholas J, Yi S Stephen, Andresen Vibeke, Gjertsen Bjørn Tore, Falini Brunangelo, Rau Rachel E, Brunetti Lorenzo, Sahni Nidhi, Goodell Margaret A, Riback Joshua A
Abstract excerpt
During cancer development, mutations promote changes in gene expression that cause transformation. Leukemia associated with aberrant HOXA expression is driven by translocations of nucleoporin genes or KMT2A as well as mutations in NPM1. The mechanistic convergence of these disparate mutations remains elusive. Here, we demonstrate that mutant nucleophosmin 1 (NPM1c) forms nuclear condensates in human cell lines,...
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