Article

Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid Leukemia

2025-05-28

Abstract excerpt

<h4>Summary</h4> During cancer development, mutations promote gene expression changes that cause transformation. Leukemia is frequently associated with aberrant HOXA expression driven by translocations in nucleoporin genes or KMT2A , and mutations in NPM1 . How disparate mutations converge on this regulatory pathway is not understood. Here we demonstrate that mutant NPM1 (NPM1c) forms nuclear condensates in mu...

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Literature Corpus work: 5c2db1b6-a4ff-520f-b02a-a3fba2582d61
DOI: 10.1101/2025.05.23.655671

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