Article

MLF2 modulates phase separated nuclear envelope condensates that provoke dual proteotoxicity

2021-10-27

Abstract excerpt

DYT1 dystonia is a highly debilitating neurological movement disorder arising from mutation in the AAA+ ATPase TorsinA. The hallmark of Torsin dysfunction is nuclear envelope blebbing resulting from defects in nuclear pore complex biogenesis. Whether blebs actively contribute to disease manifestation is presently unknown. We report that FG-nucleoporins in the bleb lumen undergo phase separation and contribute to D...

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Literature Corpus work: ef26eeeb-0703-5384-8f1a-0f84e4bfdd8a
DOI: 10.1101/2021.10.26.465916

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