Article

Lifting the ban on nuclear import activates Gdown1-mediated modulation of global transcription and facilitates adaptation to cellular stresses

2022-03-30

Abstract excerpt

<h4>ABSTRACT</h4> Dynamic regulation of transcription is crucial for cellular response to various environmental or developmental cues. Gdown1 is a ubiquitously expressed, RNA polymerase II (Pol II) interacting protein, essential for embryonic development. It tightly binds Pol II in vitro and competitively blocks binding of TFIIF and other transcriptional regulatory factors, yet its cellular functions and regulat...

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Literature Corpus work: ff715ad0-0653-5d84-a003-5ebc6bf50b1c
DOI: 10.1101/2022.03.29.486178

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