Article

An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput screens

2021-04-12

Abstract excerpt

The trafficking of specific protein cohorts to the correct subcellular location at the correct time is essential for every signaling and regulatory process in biology. Gene perturbation screens could provide a powerful approach to probe the molecular mechanisms of protein trafficking, but only if protein localization or mislocalization can be tied to a simple and robust phenotype for cell selection, such as cell p...

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Literature Corpus work: 5ff17c6e-d6da-542b-9e2a-754d6ed4857a
DOI: 10.1101/2021.04.11.439362

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