Article

Engineered kinesin motor proteins amenable to small molecule inhibition

2016-03-07

Abstract excerpt

<h4>ABSTRACT</h4> The human genome encodes 45 kinesins that drive cell division, cell motility, intracellular trafficking, and ciliary function. Determining the cellular function of each kinesin would be greatly facilitated by specific small molecule inhibitors, but screens have yielded inhibitors that are specific to only a small number of kinesins, likely due to the high conservation of the kinesin motor domain...

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Literature Corpus work: d5c5e0a1-e820-539d-b004-a430c9782827
DOI: 10.1101/042663

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