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Article

Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.

Cell - 19 Apr 2018

Yoshizawa Takuya, Ali Rustam, Jiou Jenny, Fung Ho Yee Joyce, Burke Kathleen A, Kim Seung Joong, Lin Yuan, Peeples William B, Saltzberg Daniel, Soniat Michael, Baumhardt Jordan M, Oldenbourg Rudolf, Sali Andrej, Fawzi Nicolas L, Rosen Michael K, Chook Yuh Min

Abstract excerpt

Liquid-liquid phase separation (LLPS) is believed to underlie formation of biomolecular condensates, cellular compartments that concentrate macromolecules without surrounding membranes. Physical mechanisms that control condensate formation/dissolution are poorly understood. The RNA-binding protein fused in sarcoma (FUS) undergoes LLPS in vitro and associates with condensates in cells. We show that the importin...

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Identifiers

PMID: 29677513
DOI: 10.1016/j.cell.2018.03.003
PMCID: PMC6234985

Genes

FUS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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