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A CRISPRi/a platform in iPSC-derived microglia uncovers regulators of disease states

2021-06-16

Abstract excerpt

<h4>ABSTRACT</h4> Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbations in human iPSC-derived microglia. We developed an efficient eight-day protocol for the generation of microglia-like cells based on the inducible e...

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Literature Corpus work
f5e1f08d-9df0-57d6-83c5-87f8746b8474
DOI
10.1101/2021.06.16.448639
Open publication

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A CRISPRi/a platform in iPSC-derived microglia uncovers regulators of disease statesDOI 10.1101/2021.06.16.448639
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